Comments on: A Drug to Keep Anxious Dogs Calm http://www.itchmo.com/reconcile-dog-anxiety-drug-433 Essential news for cats, dogs and pet owners. Sat, 21 Nov 2009 07:29:12 +0000 http://wordpress.org/?v=2.2.2 By: The Rise And Rise Of The Pet Industry | Itchmo: Cat & Dog News http://www.itchmo.com/reconcile-dog-anxiety-drug-433#comment-43303 The Rise And Rise Of The Pet Industry | Itchmo: Cat & Dog News Mon, 06 Aug 2007 18:04:10 +0000 http://www.itchmo.com/reconcile-dog-anxiety-drug-433#comment-43303 [...] companies are jumping in the pet industry band wagon also. There is an anxiety drug for dogs or even a diet pill if your pet is a little on the round side. Americans are expected to spend 52% [...] […] companies are jumping in the pet industry band wagon also. There is an anxiety drug for dogs or even a diet pill if your pet is a little on the round side. Americans are expected to spend 52% […]

]]> By: Elanco Animal Health Warned On Dog Anxiety Medicine Advertisement | Itchmo http://www.itchmo.com/reconcile-dog-anxiety-drug-433#comment-36548 Elanco Animal Health Warned On Dog Anxiety Medicine Advertisement | Itchmo Thu, 19 Jul 2007 07:55:23 +0000 http://www.itchmo.com/reconcile-dog-anxiety-drug-433#comment-36548 [...] The FDA has issued a warning letter to Elanco Animal Health about misleading advertisements, sales brochures, and product website for Reconcile, a medicine used to treat separation anxiety in dogs. [...] […] The FDA has issued a warning letter to Elanco Animal Health about misleading advertisements, sales brochures, and product website for Reconcile, a medicine used to treat separation anxiety in dogs. […]

]]> By: mal http://www.itchmo.com/reconcile-dog-anxiety-drug-433#comment-6083 mal Thu, 19 Apr 2007 03:15:00 +0000 http://www.itchmo.com/reconcile-dog-anxiety-drug-433#comment-6083 Sorry about the wrong links being listed. These are the FDA reports on phenobarbital: http://www.fda.gov/cvm/FOI/DFappend.htm http://www.fda.gov/cvm/FOI/dfchart.htm http://www.fda.gov/cvm/Policy_Procedures/DFreport.doc This was a comment from the study on the use of fluoxetine in dogs: Conclusions: This study demonstrated that fluoxetine has a variable individual safety response and a narrow margin of safety, as one dog who received the equivalent of 0.87 mg/kg/day (0.43 times the maximum recommended RECONCILE chewable tablets dose of 2 mg/kg/day) experienced a seizure. Other adverse reactions may be observed at less than the minimum recommended dose of 1 mg/kg/day. Resolution of most of the adverse reactions, with the exception of decreased weight gain, was achieved by discontinuation of fluoxetine administration. My comment is that phenobarbital itself may present problems as stated above with the "margin of safety". That in addition to the fact that phenobarbital exists in some degree in pet foods as stated by the FDA (although they consider it safe levels) could cause unknown reactions with the accumulated levels. This was not meant as "the rantings of deluded conspiracy theorists". I merely posted the wrong links. I have gathered a lot of information in the last month and made a legitimate error in my posting. Sorry about the wrong links being listed. These are the FDA reports on phenobarbital:

http://www.fda.gov/cvm/FOI/DFappend.htm
http://www.fda.gov/cvm/FOI/dfchart.htm
http://www.fda.gov/cvm/Policy_.....report.doc

This was a comment from the study on the use of fluoxetine in dogs:

Conclusions: This study demonstrated that fluoxetine has a variable individual safety response and a narrow margin of safety, as one dog who received the equivalent of 0.87 mg/kg/day (0.43 times the maximum recommended RECONCILE chewable tablets dose of 2 mg/kg/day) experienced a seizure. Other adverse reactions may be observed at less than the minimum recommended dose of 1 mg/kg/day. Resolution of most of the adverse reactions, with the exception of decreased weight gain, was achieved by discontinuation of fluoxetine administration.

My comment is that phenobarbital itself may present problems as stated above with the “margin of safety”. That in addition to the fact that phenobarbital exists in some degree in pet foods as stated by the FDA (although they consider it safe levels) could cause unknown reactions with the accumulated levels.

This was not meant as “the rantings of deluded conspiracy theorists”. I merely posted the wrong links. I have gathered a lot of information in the last month and made a legitimate error in my posting.

]]> By: Puff http://www.itchmo.com/reconcile-dog-anxiety-drug-433#comment-5308 Puff Tue, 17 Apr 2007 20:34:37 +0000 http://www.itchmo.com/reconcile-dog-anxiety-drug-433#comment-5308 Mal, did you read your own links? From the first one Renconcile is fluoxetine: http://en.wikipedia.org/wiki/Fluoxetine The phenobarbitol was given to one of the dogs having seizures in an attempt to save it (humans get seizures from AD meds too, but usually it isn't deadly unless you're driving at the time). Based on the info at crazymeds (best independent site with info on AD's and others) http://www.crazymeds.org/prozac.html the doages seem rather steep, and it was nasty of them to trial 10x and then kill most of those dogs. Second link also has no phenobarbital in it, just http://en.wikipedia.org/wiki/Formaldehyde. Formaldehyde is nasty enough by its self, and I find it interesting that the wikipedia page mentions it in connection with melamine. But really, spreading random dis-information isn't going to keep any more pets from being killed, and makes it easy to dismiss "internet rumors" as the rantings of deluded conspiracy theorists. Mal, did you read your own links? From the first one Renconcile is fluoxetine: http://en.wikipedia.org/wiki/Fluoxetine The phenobarbitol was given to one of the dogs having seizures in an attempt to save it (humans get seizures from AD meds too, but usually it isn’t deadly unless you’re driving at the time). Based on the info at crazymeds (best independent site with info on AD’s and others) http://www.crazymeds.org/prozac.html the doages seem rather steep, and it was nasty of them to trial 10x and then kill most of those dogs.

Second link also has no phenobarbital in it, just http://en.wikipedia.org/wiki/Formaldehyde.
Formaldehyde is nasty enough by its self, and I find it interesting that the wikipedia page mentions it in connection with melamine. But really, spreading random dis-information isn’t going to keep any more pets from being killed, and makes it easy to dismiss “internet rumors” as the rantings of deluded conspiracy theorists.

]]> By: mal http://www.itchmo.com/reconcile-dog-anxiety-drug-433#comment-5240 mal Tue, 17 Apr 2007 15:45:27 +0000 http://www.itchmo.com/reconcile-dog-anxiety-drug-433#comment-5240 Before rushing out to buy this drug check out the background on it. Also note how they killed dogs to find out the highest tolerable level that could be used: http://www.fda.gov/cvm/FOI/141-272o011907.pdf This drug is merely a form of phenobarbital, which has some problems at higher levels causing kidney failure. Consider that there is already phenobarbital in pet foods, which is considered safe by the FDA: http://www.fda.gov/cvm/FOI/C2215_EA.pdf By combining drugs on several different levels the postential for serious problems is very possible. The interesting idea behind the develpment of this drug is that dogs are being treated for separation anxiety, which indeed gives them a status much closer to people than as "merely possessions". I cannot remember the last time my car or house or furniture showed signs of separation anxiety. Can you?? Before rushing out to buy this drug check out the background on it. Also note how they killed dogs to find out the highest tolerable level that could be used:

http://www.fda.gov/cvm/FOI/141-272o011907.pdf

This drug is merely a form of phenobarbital, which has some problems at higher levels causing kidney failure.

Consider that there is already phenobarbital in pet foods, which is considered safe by the FDA:
http://www.fda.gov/cvm/FOI/C2215_EA.pdf

By combining drugs on several different levels the postential for serious problems is very possible.

The interesting idea behind the develpment of this drug is that dogs are being treated for separation anxiety, which indeed gives them a status much closer to people than as “merely possessions”. I cannot remember the last time my car or house or furniture showed signs of separation anxiety. Can you??

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