Pre-malignant mammary lesions in dogs and humans display many of the same characteristics, a discovery that could lead to better understanding of breast cancer progression and prevention for people and pets, said a Purdue University scientist from the School of Veterinary Medicine.
A group of scientists including Sulma Mohammed have found similarities between benign lesions that are considered to carry risk for developing breast cancer in both canines and humans.
“Dogs develop these lesions spontaneously in contrast to other available models and are exposed to the same environmental risk factors as humans,” said Mohammed, an associate professor in comparative pathobiology. “These shared features make the dog an ideal model to compare the breast lesions that will progress to cancer and those that will regress. Such a model will facilitate customized treatment and prevention strategies.”
The scientists studied 212 tissue biopsies from 200 female dogs with tumors that were retrieved from the archives of the Purdue Animal Disease Diagnostic Laboratory and the Veterinary Teaching Hospital as well as from the Institute of General Pathology and Anatomical Pathology at Sassari University.
The canine slides were compared to human specimens collected from the Department of Pathology at the IU School of Medicine. Mohammed said the focus of the study was not on the tumor but on the precancerous, or preneoplasia, lesions in tissue around the tumor.
“We found that preneoplasia lesions are virtually identical, microscopically, in dogs and women,” she said. “In fact, many of the slides were so similar it was often difficult to determine if they were from dogs or people without looking at the label.”
“Establishing an animal model is paramount for testing new treatment and prevention modalities, especially for lesions that express none of the targeted receptors, such as triple-negative types, before human clinical trials,” Mohammed said.
The team determined that because of the frequency of lesions, their association with spontaneous mammary cancer and the resemblance to human lesions, dogs may be the ideal model to study human breast cancer progression as well as prevention and treatment. Mohammed emphasized that the research results would benefit both dogs and humans.
Much of the difficulty in research on dogs with breast cancer is that the data is outdated, Mohammed said. According to a 1969 study of female dogs over 4 years old that were not spayed, one out of four were expected to develop mammary neoplasia, or abnormal cell growth that may progress to cancer. Thirty percent to 50 percent of canine mammary tumors were malignant, and 50 percent to 75 percent of these recurred or metastasized within one to two years.
“Women have become more aware and conscientious of conducting their own breast self-exams, and pet owners also are more aware to check their animals,” Mohammed said. “With better diagnostic tools and early detection, we are able to give dogs the same treatment that we give humans.”
Mohammed said the dogs provide a more realistic comparison to humans than the mice and rat models, in part because the tumors developed spontaneously, just as in humans. Dogs have been evaluated in a few studies, but rodent research is more common, she said.
“This is a very large, untapped resource for comparative oncology research,” Mohammed said. “Unlike laboratory rodents, dogs share a common environment with people and, therefore, may be exposed to some of the same carcinogens. Also, because dogs have a shorter life span than people, it is possible to study mammary lesions and invasive tumors that develop after a few years instead of decades.”
As a next step, Mohammed will determine the prevalence of lesions in dogs with no tumors. In addition, she will be looking at cats, which have a 90 percent malignancy rate when they are diagnosed with breast cancer.